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Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake  

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Resource details

Resource ID

76

Default
Publication
Retraction
Retraction Case 1
Retraction Case 2

Date

09 May 2019

Authors

Vivek R Yadav, Sahdeo Prasad, Ramaswamy Kannappan, Jayaraj Ravindran, Madan M Chaturvedi, Lauri Vaahtera, Jaakko Parkkinen, Bharat B Aggarwal

Publisher

Elsevier

Journal

Biochemical Pharmacology

Subjects

BLS - Basic Life Sciences/Biochemistry,BLS - Basic Life Sciences/Biology - Cellular,BLS - Basic Life Sciences/Biology - Molecular,HSC - Human Science/Medicine/Medicine - Pharmacology

Publication Date

23 June 2010

DOI

10.1016/j.bcp.2010.06.022

Manipulation status

Retraction

Retraction DOI

10.1016/j.bcp.2015.11.007

Related links

https://pubpeer.com/publications/7460E0738A16FAE33340D97491CE5C , https://retractionwatch.com/2016/02/22/journal-retracts-7-papers-by-md-anderson-researcher-long-under-investigation/

Manipulated Image

5A

Manipiulation category 1

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Comment 1

"Images in Figure 5A were reused to represent different experimental conditions: curcumin uptake in KBM-5 cells treated with curcumin alone at 30 minutes, and curcumin uptake in KBM-5 cells treated with cyclodextrin-complexed curcumin (CDC) at 45 minutes" (see Retraction Notice)

Manipulated Image

5A

Manipiulation category 2

duplicate - self

Comment 2

"Images from Figure 5A were reused in Figure 2A of reference [2] to represent different experimental conditions: four of the control images of cellular uptake of curcumin shown in Figure 5A (45, 60, 120 and 180 min) are also shown in Figure 2A (45, 60, 120 and 180 min) of reference [2]"
Reference [2]: Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo Biochem Pharmacol 79 2010 330–338 http://dx.doi.org/10.1016/j.bcp.2009.09.003

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